{"id":255880,"date":"2023-04-12T13:15:47","date_gmt":"2023-04-12T11:15:47","guid":{"rendered":"https:\/\/www.fqeuskadi.org\/?p=255880"},"modified":"2023-04-12T13:15:51","modified_gmt":"2023-04-12T11:15:51","slug":"orkambik-fkaren-biriketako-kaltea-murrizten-duela-dirudi","status":"publish","type":"post","link":"https:\/\/www.fqeuskadi.org\/eu\/orkambik-fkaren-biriketako-kaltea-murrizten-duela-dirudi\/","title":{"rendered":"Orkambik\u00a0FKaren\u00a0biriketako\u00a0kaltea\u00a0murrizten\u00a0duela\u00a0dirudi\u00a0eskolaurreko\u00a0adinean\u00a0dauden\u00a0haurrengan"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Ikerketa\u00a0baten\u00a0arabera,\u00a0tratamenduak\u00a0eritasunaren\u00a0progresioa\u00a0alda\u00a0dezake\u00a0oso\u00a0paziente\u00a0gazteengan.<\/h3>\n

Saiakuntza kliniko txiki baten arabera, Orkambik<\/b> (lunacaftor\/ivacaftor) biriketako kalte estrukturala <\/b>murriztu dezakela dirudi, toraxaren erresonantzia magnetiko<\/b> batek neurtutakoaren arabera, Fibrosi Kistikoa (FK) duten eta F508del mutaziorako homozigotoak diren eskolaurreko adineko haurren kasuetan.<\/p>\n

Ikerketa horrek iradokitzen duenez, \u201cOrkambik FK gaixotasunaren progresioa alda dezake<\/b> bizitzaren etapa goiztiar<\/b> batean ematen denean\u201d, idatzi zuten ikertzaileek, eta adierazi zuten aurkikuntzek \u201ctoraxeko erresonantzia<\/b> magnetikoa erabilgarria dela eskolaurreko adinean FQ duten haurren tratamenduaren onura ebaluatzeko, eta toraxeko erresonantzia magnetikoen potentzial <\/b>hori babesten duela\u201d.<\/p>\n

Orkambi F508del homozigotoak<\/b> diren pazienteentzat (FK eragiten duen mutaziorik arruntena), CFTR proteinarekin bat egin eta behar bezala funtzionatzen lagun dezaketen bi CFTR modulatzaileen konbinazio bat da. Homozigoto, CFTR mutazioa genearen bi kopietan<\/b> dagoela esan nahi du (guraso bakoitzeko bat).<\/p>\n

Vertex-ek 2. faseko saiakuntza kliniko bat egin zuen (NCT03625466), Orkambik bizitzako lehen etapetan FKren progresioari <\/b>nola eragiten dion hobeto bereizteko.<\/p>\n

Orkambiren efektuak haur txikietan<\/h3>\n

Ikerketan FK duten Alemaniako 2 eta 5 urte bitarteko 51 haurrek<\/b> parte hartu zuten. Guztiak homozigotoak ziren F508del-entzat. Lehenengo urtean, 35 parte-hartzailek<\/b> tratamendua jaso zuten Orkambirekin, eta 16k plazeboa<\/b>.<\/p>\n

Erresonantzia magnetikoaren puntuazio globalak 1,7 puntu<\/b> hobetu ziren, batez beste, Orkambi hartu zuten pazienteetan, ia urtebete igaro ondoren; plazeboa jaso zutenentzat, berriz, 0,3 puntu <\/b>baino ez.<\/p>\n

\u201cEmaitza horiek, MRIren puntuazio globalean atzemandako aldaketekin batera, gero eta handiagoa den ebidentzia-multzoari gehitzen zaizkio, zeinak frogatzen baitute biriketako gaixotasun azpiklinikoa goiz garatzen dela<\/b> FQ duten haurretan, eta 2 eta 5 urte bitarteko haurretan CFTR modulatzaileekin egindako esku-hartzeak biriken funtzioa hobetu dezakeela<\/b> eta birika-funtzioaren narriadura denborarekin moteltzeko aukera ematen duela\u201d, idatzi zuten ikertzaileek.<\/p>\n

Jatorrizko albistea<\/a><\/p>\n

Beste albisteak: Kaftrio\/Trikafta erabiltzen duten FK duten pazienteek bizi-itxaropen \u201cia normala\u201d izan dezakete<\/a><\/p>\n

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Ikerketa\u00a0baten\u00a0arabera,\u00a0tratamenduak\u00a0eritasunaren\u00a0progresioa\u00a0alda\u00a0dezake\u00a0oso\u00a0paziente\u00a0gazteengan. Saiakuntza kliniko txiki baten arabera, Orkambik (lunacaftor\/ivacaftor) biriketako kalte estrukturala murriztu dezakela dirudi, toraxaren erresonantzia magnetiko batek neurtutakoaren arabera, Fibrosi Kistikoa (FK) duten eta F508del mutaziorako homozigotoak diren eskolaurreko adineko haurren kasuetan. Ikerketa horrek iradokitzen duenez, \u201cOrkambik FK gaixotasunaren progresioa alda dezake bizitzaren etapa goiztiar batean ematen denean\u201d, idatzi zuten ikertzaileek, eta adierazi zuten […]<\/p>\n","protected":false},"author":1,"featured_media":255875,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[47],"tags":[],"class_list":["post-255880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fq-berriak"],"yoast_head":"\nOrkambik\u00a0FKaren\u00a0biriketako\u00a0kaltea\u00a0murrizten\u00a0duela\u00a0dirudi<\/title>\n<meta name=\"description\" content=\"Saiakuntza kliniko baten arabera, Orkambik biriketako kalte estrukturala murriztu dezake, erresonantzia magnetiko batek neurtutakoaren arabera.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fqeuskadi.org\/eu\/orkambik-fkaren-biriketako-kaltea-murrizten-duela-dirudi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Orkambik\u00a0FKaren\u00a0biriketako\u00a0kaltea\u00a0murrizten\u00a0duela\u00a0dirudi\" \/>\n<meta property=\"og:description\" content=\"Saiakuntza kliniko baten arabera, Orkambik biriketako kalte estrukturala murriztu dezake, erresonantzia magnetiko batek neurtutakoaren arabera.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fqeuskadi.org\/eu\/orkambik-fkaren-biriketako-kaltea-murrizten-duela-dirudi\/\" \/>\n<meta property=\"og:site_name\" content=\"FQ EUSKADI - 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