{"id":255775,"date":"2023-03-22T16:23:36","date_gmt":"2023-03-22T15:23:36","guid":{"rendered":"https:\/\/www.fqeuskadi.org\/?p=255775"},"modified":"2023-03-22T16:23:41","modified_gmt":"2023-03-22T15:23:41","slug":"fagoenkoktelak-modu-seguruan-murrizten-du-p-aeruginosaren-karga","status":"publish","type":"post","link":"https:\/\/www.fqeuskadi.org\/eu\/fagoenkoktelak-modu-seguruan-murrizten-du-p-aeruginosaren-karga\/","title":{"rendered":"Fagoen AP-PA02 koktelak modu seguruan murrizten du P.aeruginosaren karga FK saiakuntza batean"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.19.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"p1\">AP-PA02, Fibrosi Kistikoa (FK) eta <i>Pseudomonas aeruginosak eragindako <\/i><b>arnas infekzio kronikoak <\/b>zituzten pertsonentzako fago terapia esperimentala, ondo onartua izan zen eta bakterio-karga murriztu zuen biriketan. AP-PA02ren dosi altuak <b>bakterio kargaren murrizketa <\/b>iraunkorrekin lotu ziren SWARM-Pa azterketan.<\/p>\n<p class=\"p1\">Farmakozinetikari buruzko datuek, sendagai batek gorputzean zehar eta gorputzetik kanpo egiten duen mugimenduari buruzkoak, pazienteen <b>birikei terapia modu eraginkorrean ematen zaiela <\/b>erakusten dute, beste organo batzuetan gutxieneko esposizioa izanik.<\/p>\n<p class=\"p1\">Aurkikuntza horiek AP-PA02 entseguak <b>2b faserako aurrerapena<\/b> babesten dute, denboran zehar haren eraginkortasuna zehazteko.<\/p>\n<h3 class=\"p3\">Pseudomona aeruginosak eragindako infekzio kronikoak dituzten pazienteen aurretiazko entsegua<\/h3>\n<blockquote>\n<p class=\"p1\">&#8220;Atsegin handiz gure hautagai <b>multifago nagusiaren<\/b>, AP-PA02ren, lehen lerroko datuak aurkezten dizkizuegu. Fibrosi kistikoa zuten pazienteen artean ebaluatu zen SWARM- Pa saiakuntza klinikoan&#8221;, esan zuen Mina Pastagia, Armatako zuzendari medikoak.<\/p>\n<\/blockquote>\n<p class=\"p1\">P. aeruginosa, antibiotikoen tratamenduarekiko erresistentea den bakteria bat, normalean FK duten pazienteen birikak infektatzen ditu, eta askok <b>infekzio kronikoak<\/b> garatzen dituzte. Bakterioa Fibrosi Kistikorik gabeko bronkiektasia duten pertsonengan ere badago (NCFB, ingelesezko sigletan), arnasketa-nahasmendu kroniko eta progresiboa, arnasbideetako kaltea ezaugarri duena.<\/p>\n<p class=\"p1\">AP-PA02 inhalazio-terapia batek bakteriofagoak deritzen birusak erabiltzen ditu, bakterio horiek infektatzeko eta hiltzeko gai direnak. AP-PA02 <b>fago anitzen nahasketa<\/b> bat da, konpainiaren aurreko <b>terapia baten bertsio hobetua<\/b>, helburu maila zabalagoa izateko, potentzia handiagoa izateko eta antibiotikoekiko erresistentzia prebenitzeko gai izateko diseinatua dagoena.<\/p>\n<p><a href=\"https:\/\/cysticfibrosisnewstoday.com\/news\/ap-pa02-safely-treat-pseudomonas-aeruginosa-infection\/\">Jatorrizko albistea<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AP-PA02, Fibrosi Kistikoa (FK) eta Pseudomonas aeruginosak eragindako arnas infekzio kronikoak zituzten pertsonentzako fago terapia esperimentala, ondo onartua izan zen eta bakterio-karga murriztu zuen biriketan. AP-PA02ren dosi altuak bakterio kargaren murrizketa iraunkorrekin lotu ziren SWARM-Pa azterketan. Farmakozinetikari buruzko datuek, sendagai batek gorputzean zehar eta gorputzetik kanpo egiten duen mugimenduari buruzkoak, pazienteen birikei terapia modu eraginkorrean [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":255770,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[47],"tags":[],"class_list":["post-255775","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fq-berriak"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fagoen koktelak modu seguruan murrizten du P.aeruginosaren karga<\/title>\n<meta name=\"description\" content=\"Fibrosi Kistikoa (FK) eta Pseudomonas aeruginosak eragindako arnas infekzio kronikoak zituzten pertsonentzako fago terapia esperimentala, ondo onartua 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