{"id":255201,"date":"2022-11-10T12:07:41","date_gmt":"2022-11-10T11:07:41","guid":{"rendered":"https:\/\/www.fqeuskadi.org\/?p=255201"},"modified":"2022-11-10T12:07:45","modified_gmt":"2022-11-10T11:07:45","slug":"arnastutako-nanopartikulek-biriketako-cftra","status":"publish","type":"post","link":"https:\/\/www.fqeuskadi.org\/eu\/arnastutako-nanopartikulek-biriketako-cftra\/","title":{"rendered":"Arnastutako nanopartikulek biriketako CFTRa sortzen lagun dezakete, ikerketa baten arabera"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.19.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 class=\"p1\">Oregoneko ikertzaileek jakinarazi dute nanopartikula lipidikoak eraginkorrak direla saguekin egindako azterketa batean.<\/h3>\n<p class=\"p1\">Oregoneko ikertzaileek,<strong> arnastu daitezkeen <\/strong>eta saguen birikak azido erribonukleiko mezulariaz (ARNm) eraginkortasunez hornitzen dituzten<strong> nanopartikula lipidikoak<\/strong> garatu dituzte. Horren ondorioz, <strong>zelulek<\/strong> fibrosi kistikoaren (FQ) proteina akastuna sortzen dute.<\/p>\n<blockquote>\n<p class=\"p1\">&#8220;Nanopartikula lipidikoen inhalazioak proteinen ekoizpen lokalizatua eragin zuen saguaren birikan, <strong>ez zen toxikotasunik atzeman ez biriketan<\/strong>, ez sistema osoan, eta <strong>behin eta berriz emateak biriketako proteinen ekoizpen iraunkorra<\/strong> ekarri zuen&#8221;, adierazi zuen Gaurav Sahayk, ikerketaren egile nagusi eta Oregongo Estatuko Unibertsitateko farmazia-zientzien irakasleak, unibertsitate horretako prentsa-ohar batean.<\/p>\n<\/blockquote>\n<p class=\"p1\">FKa FKren (CFTR) mintzez haraindiko konduktantzia erregulatzen duen<strong> genearen alterazioek<\/strong> eragiten dute, eta horrek CFTR proteina akastuna sortzen du. Urritasun horrek birikak <strong>deshidratatzea eta mukositatea metatzea dakar<\/strong>, eta horrek arnasbideak blokeatzen ditu.<\/p>\n<p class=\"p1\">2018an, Sahayk eta Oregoneko beste ikertzaile batzuek terapia potentzial berri baten balioa erakutsi zuten: lipidoen nanopartikulak (koipea), CFTRren ARNm funtzionalez beteak (proteinen sintesirako material genetikoa),<strong> etxean inhalatzeko potentzialarekin.<\/strong><\/p>\n<blockquote>\n<p class=\"p1\">&#8220;Nanopartikula lipidikoek arrakasta izan dute txertoetan RNAm ematen, baina<strong> arnasketan oinarritutako RNAm terapia batek erronka izaten jarraitu du&#8221;<\/strong>, esan zuen Sahayk. Arazoetako bat da nanopartikula lipidikoak\u00a0 &#8220;<strong>apurtzeko joera<\/strong> dutela [..], eta, beraz, ez dira eraginkorrak&#8221;, gaineratu zuen Sahayk.<\/p>\n<\/blockquote>\n<h4 class=\"p1\">Aurrerapen berriak<\/h4>\n<p class=\"p1\">Orain, Sahayk eta lankideek beta-sitosterola erabili dute polietilenglikol (PEG) lipido batekin \u2013 nanopartikulen<strong> egonkortasuna eta mukosetan sartzeko gaitasuna handitzeko<\/strong>\u2013, aurreko iraunkortasunaren eta partikulen mugikortasunaren erronkak gainditzeko.<\/p>\n<p class=\"p1\">Sagu-eredu batean probatu zirenean, arnastutako nanopartikulek <strong>ez zuten toxikotasun-zantzurik erakutsi<\/strong> biriketan edo, gorputzeko beste atal batzuetan. Gainera, <strong>arnastutako nanopartikula horiek behin eta berriz emateak CFTR ekoizpen kontrolatua eragin zuen<\/strong> biriketan.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/cysticfibrosisnewstoday.com\/news\/inhaled-nanoparticles-could-help-lung-cftr-production-study-says\/?utm_source=CF&amp;utm_campaign=e2122f6a2a-CF_ENL_3.0_UNKNOWN&amp;utm_medium=email&amp;utm_term=0_b075749015-e2122f6a2a-74640714\">Artikulua<\/a><\/p>\n<p>Beste albisteak: <a href=\"https:\/\/www.fqeuskadi.org\/eu\/medikamendu-antiinflamatorioak-eta-biriketako-bakterioak\/\">Medikamendu antiinflamatorioek biriketako bakterioak murrizten lagun dezakete<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oregoneko ikertzaileek jakinarazi dute nanopartikula lipidikoak eraginkorrak direla saguekin egindako azterketa batean. Oregoneko ikertzaileek, arnastu daitezkeen eta saguen birikak azido erribonukleiko mezulariaz (ARNm) eraginkortasunez hornitzen dituzten nanopartikula lipidikoak garatu dituzte. Horren ondorioz, zelulek fibrosi kistikoaren (FQ) proteina akastuna sortzen dute. &#8220;Nanopartikula lipidikoen inhalazioak proteinen ekoizpen lokalizatua eragin zuen saguaren birikan, ez zen toxikotasunik atzeman ez [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":255191,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[47],"tags":[],"class_list":["post-255201","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fq-berriak"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Arnastutako nanopartikulek biriketako CFTRa sortzen lagun dezakete<\/title>\n<meta name=\"description\" content=\"Ikertzaileek arnastu daitezkeen nanopartikula lipidikoak garatu dituzte eta azido erribonukleiko mezularia (ARNm) eraginkortasunez ematen diete saguen birikei. 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